Recombinant PEDF 貨號:130-13 細胞因子
胞因子受體存在著可溶性形式，掌握可溶性細胞因子受體產生的規(guī)律及其生理和病理意義，必將擴展人們對細胞因子網絡作用的認識。檢測細胞因子及其受體的水平已成為基礎和臨床免疫學研究中的一個重要的方面。Catalog Number:
Catalog Number:
130-13
Synonyms:
Pigment epithelium-derived factor, SerpinF1, EPC-1
Description:
PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF （PEDF-R） that binds to PEDF with high affinity （1） should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration （AMD） and proliferative diabetic retinopathy （PDR）. PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues. （1） Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037.
AA Sequence:
MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV SNFGYDLYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAHFKGQWV TKFDSRKTSL EDFYLDEERT VRVPMMSDPK AVLRYGLDSD LSCKIAQLPL TGSMSIIFFL PLKVTQNLTL IEESLTSEFI HDIDRELKTV QAVLTVPKLK LSYEGEVTKS LQEMKLQSLF DSPDFSKITG KPIKLTQVEH RAGFEWNEDG AGTTPSPGLQ PAHLTFPLDY HLNQPFIFVL RDTDTGALLF IGKILDPRGP
Source:
E.coli
Purity:
Greater than 90% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Data Not Available.
Research Interests:
 | Angiogenesis/ Cardiovascular |  | Apoptosis |
 | Cancer |  | Neurobiology |
Country of Origin:
USA
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